Worcester, MA, 01613, USA
23 hours ago
Scientist II (Protein Characterization)
Contractor (Scientist II) – Biologics Developability Screening and Automation The Biologics CMC Developability team is an integral part of the Biologics CMC Drug Product Development organization. The Biologics CMC Developability team conducts **high-throughput screening** of **physicochemical properties** of discovery-stage biologic **drug candidates** to identify liabilities, helping in the selection of lead candidates for pipeline advancement. We have an exciting opportunity for a motivated scientist to join the Biologics CMC Developability team based in Worcester, MA. **Key Responsibilities:** • Conduct laboratory-based **high-throughput screening** and analytical, **biophysical,** and **biochemical characterization** of **biologic drug candidates.** Perform experiments to **screen physicochemical properties** of biologic molecules (antibodies, bispecific antibodies, antibody drug conjugates, and genetic medicine modalities) and identify liabilities that may impact drug development. • Enable automation and high-throughput screening of discovery **candidate molecules.** • Execute experimental protocols, collect results, and perform data analysis independently. • Maintain excellent documentation of work including electronic lab notebook and protocols. • Prepare and deliver concise scientific presentations of experimental results. • Oversee maintenance of key laboratory equipment and routine laboratory operations. • Build strong relationships with other team members and across groups. • Understand and adhere to corporate standards regarding code of conduct, safety, and documentation compliance. **Qualifications:** • BS or MS in Biochemistry, Biology, Chemistry (or equivalent, e.g., Chemical Engineering, Pharmaceutical Sciences) with 3+ (BS) or 1+ years (MS), biopharmaceutical industry experience preferred. • Hands-on experience in **protein biochemical and biophysical characterization.** Experience with diverse biologic formats desired. • Detailed knowledge of **protein structure, biophysical characterization, and formulation screening.** • Experience in **protein biophysical** and **biochemical characterization techniques,** including chromatography ( **size-exclusion, ion exchange and hydrophobic interaction** chromatography), differential scanning calorimetry & fluorimetry, dynamic light scattering, UV-VIS and fluorescence spectroscopy, imaged **capillary isoelectric focusing,** capillary electrophoresis, particle and **viscosity measurements.** Must be willing and able to learn new technologies as needed. • Prior experience in high-throughput automation and mass spectrometry would be beneficial. • Demonstrated track record of independent thinking, creativity, and scientific accomplishment. • Highly responsible and self-motivated. Skills to plan and conduct experiments with high quality and timely deliverables. Able to perform data analysis using MS Excel & GraphPad. • Team player with excellent collaboration and communication skills. **About US Tech Solutions:** US Tech Solutions is a global staff augmentation firm providing a wide range of talent on-demand and total workforce solutions. To know more about US Tech Solutions, please visit www.ustechsolutions.com. US Tech Solutions is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.
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