Memphis, Tennessee, USA
8 days ago
Scientist- Preclinical Design and Development Core
Join Our Team! St. Jude Children's Research Hospital is excited to announce an opening for a Scientist to join our dedicated team! This is a fantastic opportunity for those interested in developing personalized genomic therapies as part of the Preclinical Design and Development Core (PDD Core), integral to the Pediatric Translational Neuroscience Initiative at St. Jude. We design genomic therapies for children with catastrophic diseases, particularly those affecting the developing nervous system, as these hold immense potential for promoting longer survival, improved function, and enhanced quality of life. At the core, we are leading the scientific operations under St Jude’s new Blue-sky program – GEMINI (Genomic Medicine Initiative) to develop therapeutics for these rare neurodegenerative disorders. As a scientist in the Preclinical Design and Development Core (PDD core), you will apply your efforts in designing therapeutic approaches, identifying the lead therapeutics molecule, contributing to the therapeutic approval process, and observing the clinical impact of the drug– a complete bench to bedside process. In this role you will lead projects that include: Engineer personalized oligonucleotide therapeutics for cases enrolled in the GEMINI program. Utilize patient-derived in vitro platforms including iPSC and 2D/3D neuronal models to screen candidate molecules. Identify the lead drug molecule that will be utilized for the treatment of specific patients. Develop laboratory automation workflows to perform scalable oligonucleotide screening. What will you gain in this role: Being a key contributor to the development of personalized therapeutics from patient mutation identification to lead oligonucleotide molecule discovery for clinical treatment. Skills, including ASO therapeutics, antisense biology, scalable drug screening, patient-derived iPSCs and neuron platforms, high-throughput genomics, liquid handling automation. Prior experience in high-throughput molecular assays using hiPSC/derived neuron models or 3D organoids would be a plus. The job responsibilities include but are not limited to: Establishing neurodegenerative disease models to facilitate scalable oligonucleotide discovery using patient derived iPSC/neurons/3D brain organoids. Coordinate and execute the design and testing of candidate drug molecules in patient derived platforms (fibroblasts, iPSCs, and iPSC derived neurons). Contribute to the development of individualized therapeutics involving various aspects of preclinical processes, and general operations. Operating and troubleshooting liquid handler automation and robotics for high throughput cell-based assays and qPCR (384-well format). Clearly communicate with internal and external stakeholders (including strategy groups, and industry partners). Represent the lab to present results across various internal and external forums. Support monitoring of supplies and maintenance/calibration of equipment. Maintain electronic laboratory notebook and paper notebook system to document all laboratory activities. Perform other related duties to meet the goals of the department and institution. Minimum Education and/or Training for the position include: Bachelor's degree in a relevant scientific area is required. Scientist Minimum Experience: Eight (8) years of relevant post-degree work experience is required Six (6) years of relevant post-degree work experience is required with a Master's degree Three (3) years of relevant post-degree work experience is required with a PhD. Compensation In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $86,320 - $154,960 per year for the role of Scientist- Preclinical Design and Development Core. Explore our exceptional benefits! Diversity, Equity and Inclusion St. Jude Children’s Research Hospital has a diverse, global patient population and workforce, built on the principles of diversity, equity and inclusion. Our founder Danny Thomas envisioned a hospital that would treat children of the world—regardless of race, religion or a family’s ability to pay. Learn more about our history and commitment. Today, we continue the mission to advance cures and means of prevention for pediatric catastrophic diseases through research and treatment. As we accelerate this progress globally, we believe our legacy of diversity, equity and inclusion is foundational to success. With the commitment of leaders at all levels of the organization, we strive to ensure the St. Jude culture, leadership approaches and talent processes are equitable and culturally responsive. View our Diversity, Equity and Inclusion Report to learn about the hospital’s roots in diversity, equity and inclusion, where we are today and our aspirations for an even better future. St. Jude is an Equal Opportunity Employer No Search Firms St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.
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