ROLE SUMMARY:

We are seeking a talented and highly motivated Senior Computational Biologist with a strong biological and computational background to join the Oncology Research Unit (ORU) Computational Biology group. The successful candidate will collaborate closely with an exceptional team of scientists working on the development of novel ADCs and immuno-therapeutics in ORU at La Jolla, CA or Bothell, WA sites. 

Key responsibilities include the analysis of multi-omics data; bulk mRNA expression, single-cell sequencing and spatial omics data. The successful candidate is expected to apply cutting-edge bioinformatics, data science approaches to advance drug discovery programs with an emphasis on ADC development.  The successful candidate will also be responsible for analysis of biomarker data from early clinical development and translating findings into new therapeutic hypothesis. This is an exciting opportunity to collaborate with Computational Biology scientists and teams generating functional genomics, proteomics, enzymology, and structural biology data.

Position Responsibilities:

• Collaborate with bench scientists to design and execute computational analysis of omics data from drug discovery programs.

• Develop and leverage state-of-the-art computational approaches for cancer ADC development and precision medicine.

• Develop novel algorithms (including ML/AI) and workflows for the analysis of multi-modal data.

• Conduct in silico analysis to integrate, interpret, and mine internal and public data to address questions about tumor-associated antigens, predictive biomarkers, tumor indications, ADC drug combinations, and resistance mechanisms.

• Collaborate with scientists from diverse disciplines in ORU and Pfizer divisions.

• Actively participate in multidisciplinary project teams to formulate data-driven, actionable hypotheses and contribute to data packages supporting decision making.

• Present analytical results and literature reviews at project meetings as required.

Qualifications:

• Ph.D. degree or equivalent experience in computer science, bioinformatics, data science, computational biology, or similar disciplines.

• Proficiency developing and implementing computational data analysis methods for oncology drug development, preferably with experience in the pharmaceutical industry.

• Extensive experience in analyzing multi-omics next-generation sequencing data (e.g., genomics, bulk RNA-seq, single-cell sequencing, spatial omics, proteomics, etc.) for biomedical research.

• Proficiency coding/scripting in Python and R. Familiarity with Linux environments, high-performance computing, cloud computing, and broad experience with open-source bioinformatics tools.

• Deep knowledge of ADC development, immune oncology or immunology research and related tools/databases.

• Strong motivation, passion, and commitment to interdisciplinary science and techniques.

• Ability to thrive in a fast-paced environment, handling multiple projects simultaneously with different priorities and timelines.

• Excellent interpersonal skills, communication, and presentation abilities.

  
 

The annual base salary for this position ranges from $99,900.00 to $166,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.  Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.  Pfizer is an E-Verify employer.  This position requires permanent work authorization in the United States.

Research and Development