Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

Position Description

Nurix is seeking a Senior/Principal Scientist, Pharmaceutical Development with expertise in lipid and ASD-based drug delivery systems to provide scientific, technical, and hands-on leadership of small molecule oral solid formulation development and manufacturing for pre-clinical through Phase 1 clinical trial stages. Responsibilities will include but are not limited to:

Lead small molecule preclinical and clinical formulation development and characterization in support of internal Nurix development programs Manage outsourced development projects and manufacturing, including timeline and resource planning, to ensure milestones and deliverables are met efficiently Partner with Nurix Chemical Development and Analytical Development to identify optimal drug substance properties and control strategies Oversee preparation and characterization of pre-clinical drug products for in-house studies and partner with Global Supply Chain Operations for outsourced studies and clinical manufacturing Serve as drug product SME for cross-functional project teams Author and review relevant sections of regulatory filings, technical protocols, reports, etc. Manage and mentor research associates Contribute to internal and external presentations and publications.

Required Qualifications

In depth knowledge and demonstrated expertise in the design, development, scale-up, and outsourced manufacture of oral lipid-based drug delivery systems Significant knowledge and experience with design, scale-up, and outsourced manufacture of amorphous solid dispersion-based formulations design (spray drying, hot melt extrusion, tableting and encapsulation); experience with other enabled oral formulation modes a plus Prior experience in formulation of targeted protein degrader molecules (aka CTMs, degraders, PROTACS) a plus Thorough understanding of analytical techniques used for pre-formulation and characterization of oral solid dose forms including HPLC, LC-MS, XRPD, DSC, Dissolution, and KF Excellent technical problem solving and troubleshooting abilities Excellent written and oral communications skills PhD (preferred) or MS in chemistry, pharmaceutics, engineering, or related field with at least 7 years relevant industrial experience Ability to travel up to 25% of time

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy ().