At Adaptive, we’re Powering the Age of Immune Medicine.  Our goal is to harness the power of the adaptive immune system to transform the way diseases are diagnosed and treated.

As an Adapter, you’ll have the opportunity to make a difference in people’s lives. With Adaptive, you’ll create a career highlight through collaboration with bright, curious colleagues working at the apex of innovation and application.

It’s time for your next chapter. Discover your story with Adaptive.

Position Overview

Every immune system has a story to tell- the key is knowing how to listen. Our goal is to meaningfully improve people's lives by learning from the wisdom of their adaptive immune systems. It's a bold objective that we're uniquely built to achieve. At Adaptive, you'll be challenged, you'll be inspired, and you'll be part of an innovative organization making a real impact on improving the quality of life globally. No matter what your role is, you'll find a diverse, team-driven, fun culture where your contributions truly count.

We are seeking a creative, accomplished, and collaborative Protein Scientist to join Adaptive’s Antibody Discovery and Protein Science Team in Seattle, part of our Immune Medicine Division. This multidisciplinary group leverages Adaptive’s immune medicine platform, BCR and TCR discovery, and cutting-edge technology to develop differentiated, transformative therapeutics.

You will manage the scientific, strategic, and operational aspects of Protein Design and Production within the Antibody Discovery team. This includes designing, planning, and executing the generation and characterization of DNA and protein reagents essential for T cell and antibody-based therapies, as well as other novel therapeutic modalities. Collaboration is key to this role, involving close work with teams such as Computational Biology and Cellular Research & Innovation, as well as with external partners.

Key Responsibilities and Essential Functions

Design and purify high-quality recombinant proteins to support Antibody and TCR Discovery. Conduct hands-on lab research for biophysical characterization of antibodies and other proteins. Engage in antibody discovery and engineering using phage display. Support Protein Sciences needs across Antibody Discovery programs and other cross-functional projects. Provide strategic input into evaluating novel technologies and therapeutic modalities.

Position Requirements (Education, Experience, Other)

Required

Ph.D. in Biochemistry, Chemistry, Molecular Biology, Immunology, or related fields with 5+ years of experience, or a Master’s degree with 13+ years of experience. Strong scientific background in antibody discovery using immunization or display platforms. Proficiency in protein design for immunization campaigns and antibody screening/engineering. Expertise in recombinant protein expression systems, including mammalian, insect, and E. coli. Skilled in recombinant protein and antibody purification using the AKTA system (affinity, SEC, ion exchange). Experience with protein analytics (protein kinetics, epitope binning, stability) using BLI, HPLC, and DLS. Competency in molecular biology techniques such as cloning, DNA and RNA extraction, and B/T cell sequencing. Familiarity with molecular biology software (e.g., Geneious), molecular modeling (e.g., AlphaFold, Rosetta, Modeller), molecular visualization (e.g., PyMol), and data graphing (e.g., Prism). Ability to work in a fast-paced, collaborative, cross-functional environment. Experience managing work with CROs. Excellent technical presentation and writing skills. Maintaining thorough records in an electronic lab notebook (e.g., Benchling). Ability to work independently, adapt to shifting priorities, manage multiple tasks with short lead times, and identify and implement solutions.

Preferred

Industry experience preferred. Experience in molecular structural modeling. Knowledge of antibody upstream and downstream process development.

Working Conditions

This position involves working in a laboratory and may involve the handling of human biological specimens.

Physical Requirements

This role will require repetitive motions such as pipetting and the ability to stand for extended periods of time while conducting lab work.

Compensation

Salary Range: $113,500 - $170,300

Other compensation elements include:

equity grant bonus eligible

ALERT: Malicious groups posing as Adaptive employees have recently used fraudulent email aliases to extend employment offers, provide fake documents, and request sensitive personal and financial information. Legitimate Adaptive employment opportunities are initiated through our careers page and extended after multiple interviews with verified employees. Adaptive does not ask new hires to purchase anything out-of-pocket, including home office supplies and equipment. 

Interested in this position, but don’t meet all the requirements?  Adaptive is committed to building diverse, equitable, and inclusive teams across our organization.  Please consider applying even if your experience doesn’t match all the qualifications; you may be the exact candidate we’re searching for!

Adaptive is not currently sponsoring candidates requiring work authorization support for this position.

Adaptive’s posted compensation information includes a base salary (or hourly rate) range and summary of other available total compensation. The base salary range represents a minimum-to-maximum salary (or hourly rate) available to candidates upon extension of offer. Base salary is thoughtfully considered upon offer and is determined through multiple evaluation checks throughout the interview process, including: a candidate’s ability to meet minimum qualifications (skills/experience/education), a candidate’s ability to thoughtfully address preferred qualifications, current market conditions, and internal pay equity. Listed base salary is exclusive of bonus, commission, equity, differential pay, benefits, and other incentives.

Adaptive's benefits at-a-glance.

Adaptive Biotechnologies is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against based on disability. Please refer the Equal Employment Opportunity Posters for more information. If you’d like to view a copy of the company’s affirmative action plan or policy statement, please email hr@adaptivebiotech.com.

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NOTE TO EMPLOYMENT AGENCIES: Adaptive Biotechnologies values our relationships with our Recruitment Partners and will only accept resumes from those partners who have active agreements with Adaptive. Adaptive Biotechnologies is not responsible for any fees related to resumes that are unsolicited or are received by any employee of Adaptive Biotechnologies who is not a member of the Human Resources team.