**HOW MIGHT YOU DEFY IMAGINATION?** You’ve worked hard to become the professional you are today and are now ready to take the next step in your career. How will you put your skills, experience and passion to work toward your goals? At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10 million patients worldwide. Come do your best work alongside other innovative, driven professionals in this meaningful role. Senior Scientist **Live** **What you will do** Let’s do this. Let’s change the world. In this vital role you will join the Structural Biology Department at our site in South San Francisco, CA. The Structural Biology laboratory provides comprehensive molecular insights and structure-based design for drug-target assessment, mechanism of action, protein-protein and protein-ligand interactions, as well as protein engineering to facilitate drug discovery across various therapeutic areas. + Structure determination of target molecules in our small molecule and large molecule programs using X-ray crystallography and/or cryo-electron microscopy (cryo-EM) + Work closely with molecular biologists and protein biochemists in the protein expression group + Collaborate with small molecule scientists including computational scientists, medicinal chemists, and protein engineers **Win** **What we expect of you** We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a scientist with these qualifications. **Basic Qualifications:** + Ph.D. with a deep understanding of structural biology and general biochemistry + Significant post-doctoral research experience in large macromolecular complex structure determination. Knowledge of state-of-the-art protein structural biology techniques including all aspects of construct design, expression, purification, characterization, structure determination and analysis + Proven expertise on protein crystallography and/or cryo-EM single particle analysis, to determine atomic resolution structures + Experience with ubiquitin-proteasome system for protein degradation + Excellent presentation skills (written and oral) for effective team-based communication of results. + Ability to work independently and effectively within timelines and to collaborate in a multidisciplinary environment. + Skills in managing multiple projects and capability to prioritize. **Preferred Qualifications:** + Experience with other protein biochemical and/or biophysical characterization of protein complexes **Thrive** **What you can expect of us** As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being. The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications. Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including: + Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts. + A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan + Stock-based long-term incentives + Award-winning time-off plans and bi-annual company-wide shutdowns + Flexible work models, including remote work arrangements, where possible **Apply now** **for a career that defies imagination** Objects in your future are closer than they appear. Join us. **careers.amgen.com** **Application deadline** Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position. Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.