Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.

The Position

The Senior Scientist/Associate Director of Clinical Biomarkers will play a pivotal role in advancing biomarker strategies to support the clinical development of Nurix’s innovative therapies targeting protein homeostasis. As a leader in the Clinical Biomarkers team, the successful candidate will collaborate across research, clinical development, and external partnerships to drive the biomarker strategy for early phase clinical trials, with a strong emphasis on immune-mediated and inflammatory diseases. This role involves leading the design, execution, and interpretation of biomarker assays, contributing to patient selection, pharmacodynamic assessments, and the elucidation of drug mechanisms of action in immune-mediated and inflammatory disease.

Specific responsibilities include:

Lead the development, validation, and execution of clinical biomarker strategies to inform patient stratification, response prediction, and resistance mechanisms across Nurix’s clinical programs. Leverage deep expertise in immunology, inflammation, and autoimmune diseases, to design and interpret both preclinical and clinical biomarker studies. Oversee biomarker assay development, including assay qualification and execution on diverse platforms, to support pharmacodynamic and predictive biomarker analysis in clinical trials. Lead the evaluation and implementation of novel biomarker assays in both nonclinical models and patient-derived samples, ensuring alignment with clinical trial objectives. Collaborate closely with multidisciplinary teams, including research scientists, clinical development, external collaborators, and contract research organizations (CROs), to ensure seamless integration of biomarker data into clinical development plans. Provide scientific and strategic input into clinical trial designs, ensuring biomarker data are effectively utilized to guide therapeutic decisions and optimize patient outcomes. Mentor and manage junior scientists, fostering a collaborative and innovative research environment. Demonstrate strong motivation, creativity, and teamwork, with excellent time management and organizational skills.

Education and Skills Requirements:

Advanced degree (M.S, Ph.D. preferred) with 4+ years of experience in a relevant scientific area within the pharmaceutical or biotech industry; candidates with a strong translational biomarker background in inflammation, immuno-oncology, and hematology are preferred. Proven expertise in the development, qualification, and implementation of clinical biomarker assays, particularly in the areas of inflammation, immuno-oncology, cancer biology, or related therapeutic areas. Extensive technical experience across diverse platforms, including flow cytometry, molecular biology, proteomics, and tissue-based assays; hands-on experience with clinical samples is a plus. Demonstrated leadership in cross-functional teams, with a track record of integrating biomarker data to influence clinical decision-making. Strong organizational and project management skills, with the ability to lead multiple projects simultaneously in a fast-paced environment. Excellent communication and interpersonal skills, with the ability to present complex biomarker data to both scientific and clinical audiences, as well as external stakeholders. Innovative mindset with a proactive approach to problem-solving and a strong motivation to drive scientific excellence in biomarker research.

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