About the Work Unit: The mission of the Mass Spectrometry Research Center (MSRC) is to bring state-of-the-art mass spectrometry expertise, methodology, and instrumentation to researchers at Vanderbilt University and Vanderbilt University Medical Center. The MSRC Schey lab occupies 2,500 square feet of laboratory space, and has two LC-MS/MS instruments, including one LTQ Velos ion trap and a Waters Xevo G2S QTOF instrument with HDX capabilities. Support for the laboratory comes from NIH- and ARPA-H funded projects. Key Functions and Expected Performance: Research + Execution of HDX-MS and XL-MS workflows + Follow specific workflows for sample preparation, including deuterium labeling, protein crosslinking, protein digestion, and sample clean-up + LC-MS/MS instrument operation and acquisition of HDX-MS data + Data analysis of HDX-MS and XL-MS data + Generate monthly and quarterly reports of HDX-MS and XL-MS data, including visualization tools and protein structure figures Instrument Management + Daily operation and routine maintenance of state-of-the-art LC-MS/MS instrumentation + Operation of instrument software for instrument calibration and data acquisition + Performance of instrument QA/QC procedures Maintenance + Routine laboratory maintenance + Supply ordering + Data management + Record-keeping + Chemical waste disposal Supervisory Relationships: This position does not have supervisory responsibility. Education and Certifications: Profile of an Ideal Candidate PhD in physical or biological sciences is required. Qualifications: + At least five years of post-graduate experience required. + Laboratory experience in proteomics, biochemistry, or analytical chemistry is necessary + Experience in protein/peptide analysis using HPLC – tandem mass spectrometry (LC-MS/MS), and mass spectrometry data analysis is necessary. Skills: + Strong organizational skills + Strong written and verbal communication skills + Ability to learn and assist in development of new protocols in an evolving field Commitment to Equity, Diversity, and Inclusion At Vanderbilt University, we are intentional about and assume accountability for fostering advancement and respect for equity, diversity, and inclusion for all students, faculty, and staff. Our commitment to diversity makes us who we are. We have created a community that celebrates differences and lets individuality thrive. As part of this commitment, we actively value diversity in our workplace and learning environments as we seek to take advantage of the rich backgrounds and abilities of everyone. The diverse voices of Vanderbilt represent an invaluable resource for the University in its efforts to fulfill its mission and strive to be an example of excellence in higher education. Vanderbilt University is an equal opportunity, affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran, or any other characteristic protected by law. Please note, all candidates selected for an offer of employment are subject to pre-employment background checks, which may include but are not limited to, based on the role for which they have been selected: criminal history, education verification, social media review, motor vehicle records, credit history, and professional license verification.