Arrowhead Pharmaceuticals, Inc. (Nasdaq:  ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA.  Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. 

The Position

Are you a PhD student passionate about applying advanced computational techniques to tackle real-world drug discovery challenges? Do you want to contribute to siRNA target identification, multi-omics integration, and AI-driven drug discovery? If so, Arrowhead Pharmaceuticals is seeking two outstanding Computational Biology Summer Interns to join our team! These interns will work collaboratively, merging AI-driven insights with large-scale genetic and multi-omics data to accelerate siRNA target discovery. By leveraging machine learning, NLP-based literature mining, and genomic analysis, they will play a crucial role in prioritizing therapeutic targets and enhancing drug discovery pipelines.

This is a 12-week, fully onsite Summer Internship Program paying $25.00/hr.   

Responsibilities 

Genetic & Multi-Omics Analysis for siRNA Drug Discovery Position Analyzing All of Us and UK Biobank datasets Conducting GWAS, PheWAS, and eQTL analyses Integrating multi-omics data for neurodegenerative disease, obesity, pulmonary, and kidney disease Developing computational pipelines to prioritize siRNA targets

Preferred Skills

Python/R programming, statistical genetics, cloud computing (AWS, DNAnexus) Experience with GWAS, PheWAS, eQTL, and large-scale genetic datasets Background in computational biology, bioinformatics, or statistical genetics

Responsibilities

AI & LLMs for siRNA Target Discovery Position Leveraging Large Language Models (LLMs) and AI for target identification Extracting insights from scientific literature, clinical trial data, and multi-omics datasets Developing NLP models to automate literature review and knowledge graphs Optimizing AI-driven workflows for siRNA efficacy and safety prediction

Preferred Skills

Python, TensorFlow/PyTorch, NLP, LLMs (e.g., Hugging Face, OpenAI API) Experience in biomedical text mining, AI-driven drug discovery, and knowledge graphs Familiarity with multi-omics integration and AI for biomedical research

Requirements:

Currently enrolled doctorate student at an Accredited University or College focused on statistical genetics, bioinformatics, or computational biology or a or related area of study Experience in multi-omics data integration Familiarity with drug discovery pipelines Ability to work with machine learning methods in genomics Excellent verbal and written communication skills Strong problem-solving skills

 

California pay range $10,560—$10,560 USD

Arrowhead provides competitive salaries and an excellent benefit package.   

All applicants must have authorization to work in the US for a company.   

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