Arrowhead Pharmaceuticals, Inc. (Nasdaq:  ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA.  Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. 

The Position

Join our Discovery Chemistry team and gain hands-on experience in peptide-based drug discovery. As an intern, you will contribute to identifying and developing peptide ligands for targeted siRNA delivery by conducting scientific literature reviews and participating in lab-based synthesis, purification, and analysis. You will also support lead optimization efforts, helping to evaluate peptide structures and properties to design and synthesize improved sequences. This role offers a unique opportunity to collaborate with experienced scientists, enhance lab skills, and contribute to cutting-edge therapeutic research

This is a 12 week Summer Internship Program paying $22.00/hr.   

Responsibilities

Collaborate with team members to design experiments and troubleshoot technical challenges Synthesize novel peptides using solid-phase peptide synthesis (SPPS) on both automated synthesizers and manual techniques Purify and analyze synthetic peptides using chromatography (HPLC) and mass spectrometry (LC-MS) Ensure a safe laboratory environment by following all Environmental Health & Safety (EHS) protocols and identifying potential hazards Maintain accurate and detailed records of procedures and data in an electronic laboratory notebook (ELN) Actively participate in team meetings, share research findings, and engage in scientific discussions

Requirements:

Currently enrolled student at an Accredited University or College and majoring in Chemistry, Organic Chemistry, Biochemistry, or related area of study Completion of at least one semester of organic chemistry and one semester of organic chemistry lab. Excellent verbal and written communication skills Strong problem-solving skills Eagerness to learn new techniques Ability to work in a lab setting for prolonged periods of time Ability to wear personal protective equipment as required Must be able to lift 15 pounds at a time California pay range $10,560—$10,560 USD

Arrowhead provides competitive salaries and an excellent benefit package.   

All applicants must have authorization to work in the US for a company.   

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