Arrowhead Pharmaceuticals, Inc. (Nasdaq:  ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA.  Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. 

The Position

The intern will be paired with a Scientist for the duration of the internship. They will gain an understanding of preclinical drug development at Arrowhead and collaborate with the team to develop, optimize, and validate ligand-binding assays for specific drug targets. Throughout the project, the intern will contribute to problem-solving and decision-making processes. They will also review relevant literature on the drug targets and present their project findings to the team or a broader audience at the conclusion of the internship.

This is a 12-week, fully onsite Summer Internship Program paying $21.00/hr. 

Responsibilities

Conduct/execute studies to facilitate drug discovery and development Supports team in new target validation Occasionally present research findings to project team Occasionally read relevant scientific literature and propose applications to projects to troubleshoot and solve problems Maintain a high level of productivity in the lab and perform critical experiments Excellent laboratory work notebook record keeping

Requirements:

Current graduate student obtaining a Masters Degree in Biochemistry, Biology, Chemistry, Engineering, or related area of study Excellent verbal and written communication skills Strong problem-solving skills Eagerness to learn new techniques Ability to work in a lab setting for prolonged periods of time Ability to wear personal protective equipment as required Must be able to lift 15 pounds at a time

Preferred:

Experience in standard cellular and molecular biology techniques (i.e, Cell culture, ELISA, Cell-based assays, Immunofluorescence, Western blotting, Microscopy, Protein extraction) Knowledge of CNS disease Wisconsin pay range $10,080—$10,080 USD

Arrowhead provides competitive salaries and an excellent benefit package.   

All applicants must have authorization to work in the US for a company.   

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