At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options.
What We Do:Neurocrine Biosciences is a neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, endocrine and psychiatric disorders. The company’s diverse portfolio includes FDA-approved treatments for tardive dyskinesia, Parkinson’s disease, endometriosis* and uterine fibroids*, as well as clinical programs in multiple therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. *in collaboration with AbbVie
About the Role:The successful candidate will independently conduct laboratory experiments in support of Chemical Development projects. Initially, analytical support will be provided to the Neurocrine late-stage program working collaboratively with international CMO organizations ensuring methods for regulatory starting materials and intermediate methods are ready for validation at these organizations. In addition to familiarity with headspace GC, modern HPLC, and MS, the individual selected to fill this role must work collaboratively with his or her peers in a large open well equipped analytical lab. The individual who is hired is expected to effectively document research and conduct work in a safe manner in accordance with company, departmental, and regulatory guidelines._
Your Contributions (include, but are not limited to):Develops and executes instrumental methods (e.g. HPLC, GC, TGA, DSC, MS, FTIR) of analyses for development compounds, drug substances, raw materials, intermediates, drug product, and packaging materials
Accurately follows established test methods, procedures, and pharmacopeia chapters (e.g. Dissolution) to generate data essential for strategic decision making
With supervision, plans and executes in-house stability studies for drug substance’s, intermediates, and prototype drug products
With supervision and as appropriate, assists/leads the development of analytical methods, investigations for out of specification, out of trend, and/or anomalous results
With supervision, collaboratively plans and executes cross functional studies for chemical development and formulation development
Recognizes and responds to unexpected or anomalous observations in all activities
Maintains complete and accurate records of laboratory work in conformance with company standard operating procedures (SOPs) and training
Provides detailed reviews of peer generated data as well as that generated from contracted service providers
Maintains the inventory of laboratory consumables and clean glassware
Coordinates vendors service calls for repair and maintenance of laboratory instruments, with training perform routine maintenance of laboratory instrumentation, maintains complete and accurate records of instrument service and repairs in conformance with company SOPs and policies
Performs other duties as assigned
Requirements:BS/BA degree in chemistry or closely related field and 2+ years of pharmaceutical industry experience in an R&D/QC setting, including conducting HPLC analysis and troubleshooting, evaluating analytical data and drawing meaningful conclusions OR
MS/MA degree in chemistry or closely related field preferred and some similar industry experience noted above OR
PhD in chemistry or closely related field and some industry or relevant experience a plus
Proficient in using MS-Excel, MS-Word as well as data systems for computer-controlled instrumentation
Practical working knowledge of conducting HPLC analysis and troubleshooting
Some expertise in evaluating analytical data and drawing meaningful conclusions
Knowledge of cGMP expectations for laboratory records and quality systems
Ability to provide ideas for process improvements
Recognizes fundamental anomalies in data points and identifies issues in experiments / processes
Begins to understand how to think outside of the technical process and consider the impact decisions will have on the broader scientific goals
Strong knowledge of one scientific discipline
Good knowledge of scientific principles, methods and techniques
Good knowledge and demonstrated ability working with a variety of laboratory equipment/tools
Ability to work as part of a team of individuals to meet goals, tasks in a timeline driven setting
Strong computer skills
Good communications, problem-solving, analytical thinking skills
Detail oriented
Ability to meet deadlines
Good project management skills
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Neurocrine Biosciences is an EEO/AA/Disability/Vets employer.
We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don’t line up to exactly what we have outlined in the job description.